CESC (P = 1.3e-03), lung adenocarcinoma (P = 0.02), acute myeloid leukemia (P = 2.7e-03), BRCA (P = 8.6e-17), esophageal carcinoma (P = 4.8e-03), and stomach and esophageal carcinoma (P = 1.2e-07) exhibited significant differences in RNF135 copy number variations (CNV) and mRNA (Figure 4B). The gene discussed is RNF135; the disease is lung adenocarcinoma.