IRF4 and B-cell chronic lymphocytic leukemia: A genome-wide single-nucleotide polymorphism (SNP) association study in 517 CLL patients from the UK and 1438 British1958 Birth Cohort controls identified IRF4 as a major susceptible gene for CLL, identifying rs872071 SNP within the 3′ untranslated region (UTR) and rs9378805 SNP 10-kb centromeric to the 3′UTR of IRF4 gene as variants with the strongest association with risk to develop CLL.