In addition, the discovery that TDP-43 inclusions often colocalize with amyloid fibrils by the TMEM106B CTD in ALS and FTLD-U patients [37–39], suggests that the occasional ThT/ThS observed in the human specimen may arise from such structures rather than TDP-43 assemblies. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.