Even more recently it was found, by three independent groups concomitantly, that bona fide amyloid fibrils by the previously undetected endosomal and lysosomal TMEM106B C-terminal domain (CTD) are often found in aged brains of several patients suffering from different neurodegenerative diseases, including FTLD-U and ALS cases [37–39]. The gene discussed is TMEM106B; the disease is amyotrophic lateral sclerosis.