TARDBP and amyotrophic lateral sclerosis: In another report, it was shown that TDP-43 inclusions of ALS cases may bind ThS, but such features were found only in a small fraction of skein-like inclusions of the spinal cord, with amyloid characteristics being absent in most spinal cord skeins and absent altogether in round TDP-43 inclusions of the spinal cord and in all brain inclusions [28].