To sum up, the ACTH concentration is not recommended as a screening test to detect neoplasia of the pituitary pars intermedia, and the results should always be interpreted together with clinical signs, age, breed, colour, sex, feeding and health status and excitement of the horse, as well as the season, sample management and assay (Equine Endocrinology Group, 2021) (Table 2). The gene discussed is POMC; the disease is neoplasm.