PTHLH and cancer: (1987) discovered that circulating PTHrP and calcium concentrations increase in mammals with malignant neoplasia (pseudoparathyroidism/humoral hypercalcemia of malignancy), and it was described in horses with lymphoma (Mair et al., 1990; Marr et al., 1989), multiple myeloma (Barton et al., 2004), ameloblastoma (Rosol et al., 1994), squamous cell carcinoma (Karcher et al., 1990; Meuten et al., 1978), adrenocortical (Fix and Miller, 1987) and metastatic carcinoma (Cook et al., 1995).