MAPT and Alzheimer disease: Three core pathologies denote the degenerative mechanism of AD: β‐amyloid plaque deposition, neurofibrillary tangles of hyperphosphorylated tau, and sustained activation of immune response52; To clear plaques, tangles, and debris, microglia ramp up surveillance and phagocytic mechanisms, but often such activation also leads to the release of pro‐inflammatory cytokines such as IL‐1,63 IL‐6,64 MCP‐1 and TNF.65