Additionally, hypoxic stress promotes local immune suppression by driving MDSCs with higher PD‐L1 expression to accumulate in the TME,136 inducing Treg cell formation through the binding of HIF‐1 to the forkhead box P3 (Foxp3) promoter region in CD4+ T cells,137 and attracting Tregs to the TME through the increased secretion of chemokine (C‐C motif) ligand 28 (CCL28) by ovarian tumour cells.138. Here, FOXP3 is linked to ovarian neoplasm.