TEM‐8 targeted CAR‐T cells can successfully block tumour neovasculature,44 and TEM‐1 targeted CAR‐T cells, with the employment of a tri‐lobed bi‐specific T cell engager with anti‐CD3 scFv moiety, can be activated to prevent tumour establishment in vivo.45 This evidence concerns the gene ANTXR1 and neoplasm.