These modified CD70 CARs expressing CXCR1 (CAR‐R1) or CXCR2 (CAR‐R2) showed more efficient tumour trafficking than the control CD70 CAR only groups after therapy, and the tumour shrinkage was also observed in CAR‐R1 and CAR‐R2 groups while the control CAR and vector‐transduced groups failed to control the tumour growth in mice. This evidence concerns the gene CXCR2 and neoplasm.