TGFB2 and cancer: Studying in more detail TGFB2 as a candidate direct transcriptional target of JUNB (Additional file 1: Fig. S3 and Additional file 6: Table S5) was of particular interest, not only because it was one of the most upregulated genes upon JUNB RNAi in U2OS cells (Additional file 2: Table S1), but also because its protein product has formerly been reported to inhibit proliferation of carcinoma cells [32] and to promote both cell invasion and cancer progression [47, 48].