Recently, Xue et al. [3] comprehensively analyzed a total of 133 cHCC-ICC cases and revealed that combined type of cHCC-ICC acquired intense ICC-like landscapes, including high expression of KRT19 but a lower expression of HCC markers (including AFP and GPC3), which is also supported by our transcriptome data (Fig. 2A). This evidence concerns the gene GPC3 and intrahepatic cholangiocarcinoma.