Notably, IHC staining was strongly positive for p-AKT, p-ERK, p–NF-κB, β-catenin, and TGF-β in the ICC component of the MAPEpo tumors, where FGFR2 served as the positive control (Fig. 3B). The gene discussed is FGFR2; the disease is intrahepatic cholangiocarcinoma.