Similarly, in breast cancer patients, high HP-[1-13C]pyruvate to HP-[1-13C]lactate conversion rates identified strongly glycolytic aggressive triple negative breast cancer with high HIF1a and MCT1 tissue expression [28] and high-grade lesions in prostate cancer with increased MCT4 expression [29]. The gene discussed is SLC16A3; the disease is triple-negative breast carcinoma.