In addition, methyl-CpG-binding domain 2 (Mbd2) selectively bound to methylated CpG DNA within the erythroid differentiation regulator 1 (Erdr1) promoter to inhibit its expression, which promoted fibroblasts to differentiate into myofibroblasts by enhancing TGF-β/Smads signaling transduction and exacerbating silica-induced pulmonary fibrosis [19]. The gene discussed is TGFB1; the disease is pulmonary fibrosis.