Combined with alleviating the fibrotic effects of miR-326 in silica particle-exposed mice model, Wu et al. found that lnc-SNHG1 remarkably adsorbed miR-326 and promoted specificity protein 1 (SP1) expression, thereby accelerating the conversion of fibroblasts to myofibroblasts and synergistically promoting the development of pulmonary fibrosis [82]. This evidence concerns the gene SP1 and pulmonary fibrosis.