By analyzing the DNA methylation spectrum in the lung tissue of silicosis, Zhang et al. revealed that the number of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and c-Jun CpG promoter methylated sites were increased in the advanced stage of silicosis, and the hypermethylation of PTEN promoter was associated with the decreased expression of PTEN protein [21]. Here, JUN is linked to silicosis.