Further analysis revealed that for higher tumor cell delivery efficacy, low TAM and CAF levels combined with a high relative ratio of CD276+Plvap+ TECs could be used as potential biomarkers to examine the suitability of the tumor itself for NP delivery (Fig. 8c–g), or, in the future upon more detailed characterization of various tumor models, may serve as tools to predict NP tumor cell delivery efficacy. Here, PLVAP is linked to neoplasm.