MAPK8 and familial pancreatic carcinoma: Although extracellular signal-regulated kinase (ERK) phosphorylation in A549 cells was not suppressed by sar-j or isoQ (data not shown), Chen et al. reported that isoQ inhibits ERK phosphorylation and promotes c-Jun N-terminal kinase (JNK) phosphorylation in pancreatic cancer cells [32].