In a recent study, a five-gene prognostic signature consisted of AURKA, PZP, RACGAP1, ACOT12 and LCAT could discriminate 1-year, 2-year, and 3-year HCC OS status with AUCs of 0.741, 0.724, and 0.718, respectively [37]. The gene discussed is AURKA; the disease is hepatocellular carcinoma.