These alkaloids have been originated to have programmed cell death-actuating action towards tumor cells in vitro and in vivo facilitated by nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and c-Jun N-terminal kinase (JNK) pathways, in which DNA injury and mitochondrial brokenness assume significant parts. The gene discussed is MAPK8; the disease is neoplasm.