To understand the specific function of MYBL2 in HCC, we generated functional knockout of MYBL2 by CRISPR/Cas9 system in HepG2 cells, and implanted the MYBL2 knockout and parental cells in the flanks of NSG mice for 3 weeks, tumor growth were retarded after loss of MYBL2 (Fig. 4A, B). Here, MYBL2 is linked to neoplasm.