Noticeably, the Stx1B-scFv OKT3 lectibody did not affect the viability of Gb3˗ Namalwa cells, excluding the presence of undesired off-target cytotoxicity, while promoting a less pronounced cell lysis of LS-174 cells, characterized by a low expression of the Gb3 antigen, which was only detectable by using higher marker concentrations.To this matter, the excellent specificity of BiTEs has made this platform an exquisite system for treating cancer. Here, STX1B is linked to cancer.