In AML it has been reported that, despite the downregulation of the DAG1 transcript, the immunolocalization pattern of α-DG and β-DG in the plasma membrane was very similar when comparing control (CD34+) cells from healthy individuals with primary blasts from AML patients or with the HL-60 and Kasumi-1 cell lines [77]. The gene discussed is DAG1; the disease is acute myeloid leukemia.