In human primary gastric carcinoma samples, as well as in the undifferentiated cell line Kato III, low levels of protein O-mannosyl glycosylation are found overall, and especially of E-cadherin, which is both detectably underexpressed and poorly O-glycosylated, this leading to a partial cytoplasmic mislocalization of the latter with loss of cell-cell adhesion capability [137]. Here, CDH1 is linked to gastric carcinoma.