DAG1 and neoplasm: When DAG1 (cDNA) was overexpressed in T4-2 cells, cell rounding (reflecting cytoskeletal changes) was elicited by laminin, cell polarity was restored and their tumorigenic potential reduced by increasing the levels of PTEN [67], a well known phosphatase acting as a tumor suppressor by inhibiting AKT/GSK-3β/Snail signaling [147].