DAG1 and leukemia: Also, decreased expression levels were observed in the HL-60 and Kasumi-1 leukemia-derived cell lines of α-DG core protein (by ‒ 1.28- and ‒ 2.00-fold, respectively), and especially of β-DG (by ‒ 6.25- and ‒ 2.17-fold), correlating with an underexpression of DAG1 mRNA (by ‒ 2.50- and ‒ 1.49-fold) [77, 85].