Furthemore, in solid tumors and derived cell lines (i.e., leaving aside leukemia) genes directly involved in the synthesis of core M3 glycan and matriglycan, such as POMGNT2, CRPPA, B4GAT1, LARGE1 and LARGE2 and/or their encoded proteins, are found downregulated (Fig. 2). Here, LARGE2 is linked to leukemia.