LARGE2 and Familial prostate cancer: Finally, decreased mRNA levels of the LARGE2 gene have been detected in the PANC-1 and BxPC-3 cell lines of pancreatic cancer, TEM4-18 of prostate cancer, A498 of renal cell carcinoma, and MDA-MB-231 and ZR-75-1 of breast cancer [87, 103], whereas in colon cancer cell lines they were highly variable [87, 128].