As part of the DGC, β-DG acts as a scaffold or multifunctional adaptor in the cytoplasm, binding to and sequestering Grb2 and other signaling proteins of the Ras/Raf/MAPK pathway, and eventually bringing about inhibition of cell division-stimulatory signals and/or enhancement of growth-inhibitory signals, thereby playing a role itself as a tumor suppressor. The gene discussed is GRB2; the disease is neoplasm.