AGR2 and breast cancer: Additionally, the overexpression and localization of β-DG in the cytoplasm could be favored by the expression of AGR2 and its interaction with proteins of the ECM, where AGR2 has been reported to disrupt cell-cell adhesion and to promote the formation of invasive structures [165], as detected in the breast cancer cell lines MCF7 and MDA-MB-453 [110].