With KRAS G12C mutated non-Sq NSCLC samples, co-mutations in STK11 and KEAP1 were more commonly associated with low (28% and 16%) or negative (53% and 27%) PD-L1 expression vs high (9.4% and 8.3%), and these associations were largely consistent across KRASm subsets. Here, STK11 is linked to non-small cell lung carcinoma.