This hypothesis is supported by the bioinformatics analyses conducted by Poppenberg et al., who in patients with unruptured intracranial aneurysms (UIA) showed that among the genes allowing to distinguish patients with cerebral aneurysms with a diagnostic accuracy of 85% from those without vascular changes in the brain, there were genes strictly related to the NF-κB pathway11. This evidence concerns the gene NFKB1 and Dilatation of the cerebral artery.