In both, the study and the control groups, CSF NF-κB p65 levels were significantly lower compared to the serum values (p < 0.0001, respectively) Fig. 1D. We also found that CSF as well as serum NF-κB p65 concentrations negatively correlated with the number of aneurysms. The gene discussed is NFKB1; the disease is aneurysm.