Significant regulation of 8 out of 14 phosphosites (termed ‘oncogene addiction phosphorylation signature’, OAPS) that are modulated by METi in MET-addicted systems was detected also in EGFR-, ALK- and BRAF-addicted cellular tumor models following EGFR, ALK and BRAF targeting, respectively. The gene discussed is EGFR; the disease is neoplasm.