Furthermore, it induced in ALS samples a decrease of DICER (p < 0.0001), RUNX3 (p < 0.0001) and NTRK3 (p < 0.01), together with an increase in NTRK2 (p < 0.05), vGluT1 (p < 0.01), SPP1 (p < 0.01) and ETV1 (p < 0.0001) and PVALB (p < 0.05). The gene discussed is PVALB; the disease is amyotrophic lateral sclerosis.