SPP1 and amyotrophic lateral sclerosis: In ALS cells, it induced a significant increase on the expression of some motor-system related genes—myelin (MPB +), peripheral neurons (PRPH +), motoneurons (MNX1 +), pSN functionality related markers (ETV1 and VGluT1), TNFSF1B and SPP1 (Fig. 4D and Fig. S2, protocols C and D)—and a decrease of DICER.