SPP1 and amyotrophic lateral sclerosis: In the results obtained, we can observe in ALS samples undergoing protocols C and D, that peripherin and TNFSF1B levels are high, as expected for ALS56,58, DICER levels are lower (only in protocol D) as observed in ataxia59,60, and SPP1 is higher, as observed in inflammatory processes of dystrophic and injured muscles61,62.