Furthermore, in ALS samples, it induced an increase of TUBB3 (p < 0.05), PRPH (p < 0.001), NTRK2 (p < 0.0001), ETV1 (p < 0.0001), SPP1 (p < 0.01), GFAP (p < 0.0001), MNX1 (p < 0.01), TNFSF1B (p < 0.01), and a decrease in DICER (p < 0.05). Here, SPP1 is linked to amyotrophic lateral sclerosis.