Compared with Cluster 2, the infiltration of CD4+ T cells and follicular helper T cells (Tfhs) that promote tumor immunity was lower in Cluster 1 (both P < 0.01, Fig. 3C, D), while the infiltration of nTreg cells and iTreg cells that inhibit tumor immunity was higher in Cluster 1 (P = 0.049, 0.000; Fig. 3E, F). Here, CD4 is linked to neoplasm.