According to what was previously mentioned, the aim of this study was to examine the impact of polymorphisms TGFB1 C-509T and Leu10Pro, XRCC1 Arg280His, XRCC3 Thr241Met as well as the radiation-induced CD8 T-lymphocyte apoptosis rate on the RT-induced normal tissue toxicity in Serbian PCa patients. Here, TGFB1 is linked to posterior cortical atrophy.