CRP and Cognitive impairment: In addition, periodontal disease presented strong association with higher risk (Fig. 4) towards: cancer (n = 9); cardiovascular disease (CVD) (n = 5); diabetes mellitus (n = 3); adverse pregnancy outcomes (APOs) (n = 2); lower longevity (n = 2); neurodegeneration (cognitive impairment and dementia) (n = 3); polycystic ovarian syndrome (PCOS) (n = 1); psoriasis (n = 1); altered levels of mean corpuscular hemoglobin (MCH) (n = 1); and, with serum CRP (n = 1).