Importantly, ALICEsen could also be activated by infection with STING-dependent pan-genus viruses29–32, including DENV-2, SARS-CoV-2, hCoV-229E, hepatitis C virus (HCV), HBV, adenovirus (ADV) and HSV-1 (Fig. 1b), indicating that ALICEsen might be used as a relative broad-spectrum sensor to detect STING-dependent viruses. This evidence concerns the gene STING1 and infection.