ADA2 and myeloid leukemia: Some examples included the upregulation of TRIB1, a transforming gene for myeloid cells35, and the matrix metallopeptidase MMP2, which presents high secretion levels in AML36; as well as the downregulation of genes such as adenosine deaminase ADA2, and the mini-chromosome maintenance proteins MCM737 and MCM4, whose repression has been involved in myeloid leukemias (Fig. 2c).