In two MDS-MLD cases, patient 14 (male, Hb 7.9 g/dL) (RNA levels after knockdown shown in Fig. S6e); and patient 15 (male, Hb 9.3 g/dL), DDIT3 knockdown promoted higher levels of CD71 expression and improved transition to stage III (Fig. S6f, g). The gene discussed is TFRC; the disease is myelodysplastic syndrome.