DDIT3 knockdown in patient 13 (RNA levels after knockdown shown in Fig. S6d), a male with MDS-MLD and anemia (hemoglobin (Hb) 11.8 g/dL), led to an increase in the percentage of cells in stage IV (CD235+ CD71-) at day 7 of differentiation, an effect that was increased at day 13, where cells expressing the control shRNA were partially blocked at stage III (Fig. 6b, c). This evidence concerns the gene TFRC and myelodysplastic syndrome.