More importantly, using our own gene signatures generated from the DEGs detected in our cohort of MDS samples, we observed that DDIT3-overexpression induced a “MDS-like” transcriptional state, activating genes upregulated in MDS patients, and repressing factors downregulated in the disease (Figs. 3e, f and S3h). The gene discussed is DDIT3; the disease is myelodysplastic syndrome.