Among them, we selected the TF DDIT3 (DNA Damage Inducible Transcript 3/CHOP/C/EBPζ) as one of the top-ranking upregulated transcriptional regulators by FC, showing a range of 2.7–10.5 FC over samples from healthy older adults in several MDS-derived HSC specimens (Fig. 2f, S3a). Here, TF is linked to myelodysplastic syndrome.