Together, these findings indicated the oncogenic function of circPLIN2 and its potential molecular mechanism in which elevated circPLIN2 participated in the development and progression of ccRCC by binding IGF2BP proteins and miR-199a-3p to regulate the expression of their target genes, including c-Myc, MARCKSL1, and ZEB1 (Fig. 8G). The gene discussed is ZEB1; the disease is nonpapillary renal cell carcinoma.