ZEB1 and nonpapillary renal cell carcinoma: In addition, circPLIN2 not only regulates the stability of the c-Myc and MARCKSL1 mRNAs by binding to the KH domains of IGF2BP proteins but also sponges miR-199a-3p to abolish the repressive effect of miR-199a-3p on ZEB1 expression, ultimately resulting in ccRCC tumorigenesis and progression.