Here, we identified mTORC1 as a “double-edged sword” in liver injury in the very early stage of the disease in the murine hepatitis model: Whereas mTORC1-activated hepatocytes secrete miR-329-3p to promote KC death, which results in an alleviation of the inflammatory response and liver injury, mTORC1-activated KCs express increased levels of CFB proteins to activate the complement alterative pathway, which aggravates hepatocyte death and liver injury (Fig. 6k). This evidence concerns the gene CALCA and Hepatitis.