Results showed that LX‐2 treated by conditioned medium from dLSECs (dLX2s) exhibited a decreased expression of α‐smooth muscle actin (αSMA) and a decreased contraction of collagen compared with that treated by conditioned medium from nLSECs (nLX2s), accompanied by decreased expression levels of genes related to liver fibrosis progression, such as ACTA2, COL1A1, and COL3A1 (Figure S17, Supporting Information). The gene discussed is COL1A1; the disease is Hepatic fibrosis.