Clinically, liver transplantation is still the only reliable treatment to prevent the deathly hurt caused by liver cirrhosis despite tremendous efforts and expenditure in therapeutics research and development.[37] In this work, we constructed a CEDSS platform for high‐throughput detection of cellular degradation ability in vitro and found that combinatory priming with accutase and PMA could effectively endow LSEC with tremendous ECM degradation ability, which was regulated by MMP expression, downstream of transcription factor c‐Fos. This evidence concerns the gene FOS and cirrhosis of liver.