Although the contribution of these mutations to pathways such as GR, IL-7, and NOTCH1 warrants investigation, a synergistic effect of USP7 haploinsufficiency with aberrant TAL-1 activation on T-ALL was observed, suggesting that the levels of USP7 are critical in TAL-1-positive cases (23). The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.