Although the contribution of these mutations to pathways such as GR, IL-7, and NOTCH1 warrants investigation, a synergistic effect of USP7 haploinsufficiency with aberrant TAL-1 activation on T-ALL was observed, suggesting that the levels of USP7 are critical in TAL-1-positive cases (23). This evidence concerns the gene TAL1 and acute lymphoblastic leukemia.