Previous studies have demonstrated important oncogenic roles for the process of deubiquitination, including stabilization of Neurogenic locus notch homolog protein 1 (Notch1) and serine/arginine-rich splicing factor 6 (SRSF6) by the deubiquitinase USP7 in T-ALL (21, 22). This evidence concerns the gene USP7 and acute lymphoblastic leukemia.