We show that EREG expression is induced by type I interferon and co-expressed with alarmins S100A8 AND S100A9, which aligns our findings to previous clinical studies that associated circulating levels of type I interferon and S100A8/A9 with severity of SSc skin and lung fibrosis (35, 48, 64). This evidence concerns the gene S100A9 and pulmonary fibrosis.