INS and infection: In the bladder, the signaling pathways most affected by the MHV infection at both time points (1 and 4 wks) included matrix remodeling (GSS for CIE 1 wk = 3.2; CIE 4 wks = 2.1); neurons/ neurotransmission (GSS for CIE 1 wk = 2.6; CIE 4 wks = 1.6); Wnt signaling (GSS for CIE 1 wk = 2.4; CIE 4 wks = 1.8); autophagy (GSS for CIE 1 wk = 2.4; CIE 4 wks = 1.6); angiogenesis (GSS for CIE 1 wk = 2.2; CIE 4 wks = 1.7); and insulin signaling (GSS for CIE 1 wk = 2.3; CIE 4 wks = 1.9).