CDH1 and Familial gastric cancer: A previous study reported that 40% of HDGC cases had CDH1 germline alterations.28 However, we detected CDH1 germline missense alterations and indels in only 8 of 284 HDGC cases (2.8%) (Figure 2A), and all of the 6 missense alterations and 2 indels had not been previously reported.