For example, Li et al48 reported an association between MUC16 alteration and outcomes in patients with GC, another study12 found that the CIC gene was highly altered among patients in a TCGA STAD cohort, and Yang et al49 found that the alteration frequencies of MUC16 and FSIP2 were high in East Asian patients with GC. This evidence concerns the gene FSIP2 and gastric cancer.