Among them, COSMIC cancer census genes, including FGFR3 (hazard ratio [HR], 2.2; 95% CI, 1.2-4.2), ASPSCR1 (HR, 2.2; 95% CI, 1.2-4.1), CIC (HR, 2.4; 95% CI, 1.2-4.7), DGCR8 (HR, 2.2; 95% CI, 1.1-4.5), and LZTR1 (HR, 2.5; 95% CI, 1.2-5.3), were altered in high frequencies (>10%), and their alterations were independently associated with worse OS (eFigure 11B-F in Supplement 1). The gene discussed is CIC; the disease is cancer.