Second, 94.0% of patients in this study were younger than 40 years and did not have a family history of diffuse GC, which may explain the low alteration rate of CDH1. Additional studies including patients with different conditions, especially those with a family history or personal history of lobular breast cancer, are warranted because patients with different conditions were not included in the present cohort. The gene discussed is CDH1; the disease is gastric cancer.