Moreover, NF-κB, p38MAPK, and high mobility group box-1 (HMGB1) are strongly stimulated in serious SARS-CoV-2 and accompanied with the progression of ALI/ARDS and thrombotic events (Al-Kuraishy et al. 2022b, 2022c). Here, NFKB1 is linked to acute respiratory distress syndrome.