Furthermore, some severity and fatality cases of COVID-19, a currently pandemic disease, are likely relevant to elevated IL-6 levels [132], Previous studies revealed that the reduction of ROS by metformin(1 mM for cells and 150 mg/kg for mice models) is capable of inhibiting calcium release-activated channels(CRAC)-mediated Ca2+ release from the endoplasmic reticulum, consecutively, inhibiting interleukin 6(IL-6) release [108, 133]. This evidence concerns the gene IL6 and COVID-19.