After treating streptozotocin-induced diabetic cardiomyopathy (DCM) mice with 200 mg/kg metformin and high glucose-treated cardiomyocytes with 2 mM metformin, Fan et al. found that metformin improves autophagy and then alleviates the pyroptosis in DCM by inhibiting the AMPK/mTOR pathway [62]. The gene discussed is PRKAA1; the disease is familial dilated cardiomyopathy.