After adjustments, the early pregnancy SHBG level was 8.7% lower (CI 95% 1.2%–15.4%) and FAI was 7.2% higher (CI 95% 1.7%–12.8%) in the women who needed long‐acting insulin as compared with other women with GDM (Table 3). The gene discussed is SHBG; the disease is gestational diabetes.