Of the women with GDM, 300 (30.3%) had early‐onset disease (diagnosed <20 weeks of gestation) (detailed characteristics in Table S1), which was independently associated with 6.7% lower SHBG (CI 95% 0.7%–12.7%) and 6.6% higher FAI (CI 95% 2.0%–11.3%) compared with the women diagnosed with GDM later in pregnancy (Table 2). The gene discussed is SHBG; the disease is gestational diabetes.