CXCL8 and cancer: For instance, cancer necrosis and hypoxia or damage of local tissue may activate an inflammatory reaction; invasion or cancer growth may cause inflammation of its tissues; and malignant disease cells, malignant cancer‐related leukocytes, or both may influence the increasing of inflammatory cytokines such as factor of neoplasm necrosis, vascular endothelial growth factor, interleukin (IL)‐1, IL‐6, and IL‐8.