Our study found that all but one of the cell lines showed overexpression of an additional three TJ genes: OCLN, F11R (JAM-A) and TJP3 (ZO-3), suggesting a more complex role for TJ deregulation in endometrial cancer involving proteins that function at different levels within the TJ network from cell to cell adhesion to cell signaling. This evidence concerns the gene OCLN and endometrial cancer.