Currently, NPs are mainly designed for imaging and treatment of atherosclerosis targets, which can be key cells and cytokines in the development of plaques, such as intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in activated endothelial cells5 and smooth muscle cells,6 macrophages,7 and foam cells in inflammatory plaques.8 The gene discussed is VCAM1; the disease is atherosclerosis.