Lin et al. [9] isolated active compound 11-epi-sinulariolide acetate from soft coral, and showed that it prevented the mechanisms of migration and invasion of HCC via inhibition of phosphorylation of ERK1/2 and p38MAPK, and inhibition of the FAK/PI3K/AKT/mTOR pathway. Here, AKT1 is linked to hepatocellular carcinoma.