Huang et al. [21] found that beta-mangostin could inhibit the migration and invasion of human HCC cells by reducing the expressions and activities of MMP-2 and MMP-9, and the process involved the activation of the MEK1/2, ERK1/2, MEK4, and JNK1/2 signaling pathways. This evidence concerns the gene MAPK8 and hepatocellular carcinoma.