Cheng et al. [17] isolated sinulariolide from coral, and showed that it could inhibit cell migration and invasion of human bladder carcinoma TSGH-8301 cell line by decreasing the expressions of MMP-2/MMP-9 and urokinase and increasing the expressions of TIMP-1/TIMP-2. The gene discussed is TIMP2; the disease is urinary bladder carcinoma.