In conclusion, we successfully identified three “real” hub genes (VEGFA, CDC25A, and LOX), and six crucial miRNAs (hsa-mir-24-3p, hsa-mir-124-3p, hsa-mir-195-5p, hsa-mir-146a-5p, hsa-mir-155-5p, and hsa-mir-23b-3p) associated with endothelial dysfunction in HPH based on bioinformatic analysis. The gene discussed is LOX; the disease is endothelial dysfunction.