Upregulation of Wnt ligands and β-catenin proteins, as well as decreased expression of the tumor-suppressors APC, AXIN-2, and GSK3β, were found to be associated with aggressive features in human cancers including brain, breast, hepatocellular (HCC), colorectal (CRC), and UT cancers (Krishnamurthy and Kurzrock, 2018[25]; Wang et al., 2019[53]; Yeh et al., 2019[68]; Shahcheraghi et al., 2020[44]; Zhang et al., 2021[71]). Here, AXIN2 is linked to neoplasm.