On the contrary, ketogenesis increases in pregnancy and the prevalence of ketoacidosis is higher in pregnant women than in non‐pregnant women: 8.9% versus 3.1%, respectively, due to the increase in the level of hormones secreted by the placenta such as placental lactogen and prolactin, which cause insulin resistance by the antagonistic effects of insulin, and by stimulating lipolysis, increasing the production of free fatty acids as a substrate for the production of body ketones.14 This evidence concerns the gene INS and diabetes mellitus.