MAPK8 and neoplasm: As shown in Figures 6F,G, the tumor tissues from platycodin D-treated mice showed a significant increase in staining of PUMA, phospho-JNK, and phospho-c-Jun(Ser63) compared to those from vehicle-treated mice, but the total JNK staining in platycodin D-treated tumors and vehicle-treated tumors is similar.