Bergenin, a type of polyphenol compound with antiulcerogenic, anti-inflammatory, and wound-healing properties that induces ABCG2 expression and suppresses SLC2A9 expression by inhibiting the nuclear translocation of p53 in HK-2 cells, reduces serum urate levels in mice with yeast polysaccharide-induced hyperuricemia by promoting renal and gut urate excretion (Chen et al., 2020). The gene discussed is TP53; the disease is hyperuricemia.