Bergenin, a C-glucoside of 4-O-methyl gallic acid isolated from several medicinal plants, has been shown to reduce serum urate levels in a hyperuricemia-induced mouse model by elevating Abcg2 expression in both the kidney and intestine and by suppressing Slc2a9 expression in the kidney (Chen et al., 2020). This evidence concerns the gene SLC2A9 and hyperuricemia.