Chrysin, a flavonoid compound naturally found in honey, propolis and mushrooms that exerts anti-inflammatory and antioxidant effects, has been shown to effectively reduce serum urate levels by inhibiting the activity of XOD in the liver of high-fructose corn syrup-fed hyperuricemia rats by downregulating the protein expression of Urat1 and Glut9 and upregulating the protein expression of Oat1 and Abcg2 (Chang et al., 2021). The gene discussed is SLC22A12; the disease is hyperuricemia.