The 70% ethanol extract (comprising polyphenols and flavonoids) of Eurycoma longifolia, a tropical medicinal plant, has been reported to significantly reduce serum urate levels by downregulating the protein expression levels of Urat1 and Glut9 in rats with PO-induced hyperuricemia and an adenine-/PO-induced hyperuricemia mouse model (Bao et al., 2019). The gene discussed is SLC22A12; the disease is hyperuricemia.