Dioscin, a spirostane glycoside with anti-inflammatory and antiallergic properties found in the rhizome of Dioscorea spongiosa, has been shown to significantly reduce serum urate by downregulating Glut9 and upregulating Oat1 in rats with PO-induced hyperuricemia alone and in mice with adenine-/PO-induced hyperuricemia (Tao et al., 2018; Zhang et al., 2018; Li J. et al., 2021). This evidence concerns the gene SLC22A6 and hyperuricemia.