Fisetin (3,3′,4′,7-tetrahydroxyflavone), a naturally occurring flavonol, reduces serum urate by modulating the expression of kidney urate transporters, including Urat1, Oat1/3, and Abcg2, via the STAT3 and TGF-β signaling pathways in mice with PO- and adenine-induced hyperuricemia (Ren et al., 2021b). Here, SLC22A12 is linked to hyperuricemia.