In an analysis of the Korean Cancer Prevention Study-II (KCPS-II) cohort, sequencing of URAT1 in 68 male Korean subjects revealed that the pattern most strongly associated with hyperuricemia included a common variant consisting of rs7929627 (IVS7-103A/G, noncoding variants), rs75786299 (IVS3+11A/G, noncoding variants) and rs3825017 (N82N, coding variant). This evidence concerns the gene SLC22A12 and hyperuricemia.