SLC17A3 and hyperuricemia: Two thiazide drugs, chlorothiazide-2 and trichlormethiazide-3, and two loop diuretics, bumetanide-4 and furosemide-5, have been shown to inhibit the urate transport activity of NPT4 in an oocyte expression system (Jutabha et al., 2011), which suggests the involvement of NPT4 in diuretic-induced hyperuricemia.