A polysaccharide (molecular weight, 46.56 kDa) obtained from the green algae Enteromorpha prolifera, comprising rhamnose, glucuronic acid, galactose, arabinose, and xylose at a molar ratio of 20.45:12.74:10.99:5.84:1.95, has been shown to significantly reduce serum urate, serum XOD and hepatic XOD; upregulate the mRNA and protein expression of urate secretion transporters Abcg2, Oat1, and Npt1; and downregulate the urate reabsorption transporter, maintaining the stability of the intestinal flora in mice with hyperuricemia (Li X. et al., 2021). This evidence concerns the gene SLC22A6 and hyperuricemia.