SLC22A12 and hyperuricemia: Baicalein, a bioactive flavonoid exhibiting antioxidant, anti-inflammatory, antihypertensive and anticancer properties, has been reported to significantly reduce serum urate and enhance renal urate excretion in mice with PO-induced hyperuricemia by specifically inhibiting the [14C]-urate uptake activities of Glut9 and Urat1 in a noncompetitive manner, with a half-maximal inhibitory concentration values of 30.17 ± 8.68 and 31.56 ± 1.37 μM, respectively (Chen Y. et al., 2021).