It also inhibits activation of the TLR 4/MyD88/NF-κB signaling pathway in the kidney and reduces the mRNA expression of ileal IL-1β and IL-6, resulting in inflammation relief in the above hyperuricemic mice and in LPS-induced acute kidney injury (Ye et al., 2017; Zhou et al., 2021). The gene discussed is IL6; the disease is acute kidney injury.