Huang et al. reported that fisetin, a naturally occurring flavonol, inhibits inflammatory responses in experimental periodontitis in rats and LPS-induced human gingival fibroblasts through the FGFR1/TLR4/NLRP3 inflammasome pathway, which mitigates kidney injury to restore the normal expression of Urat1 (Huang et al., 2021). This evidence concerns the gene SLC22A12 and periodontitis.