TLR4 and Insulin resistance: Resveratrol, a polyphenolic, non-flavonoid plant-derived antitoxin, has been shown to reduce serum urate levels by downregulating the expression levels of Glut9 and Urat1 and to improve kidney inflammation, possibly via the TLR4 AND NLRP3 signaling pathways, in mice with high-fat diet-induced insulin resistance (Zhang et al., 2021).