TLR4 and Sepsis: In a classic Sprague‒Dawley rat model of sepsis peritonitis, resveratrol significantly decreases LPS-induced expression of NF-κB, TNF-α, IL6, IL-1β, and TLR4 and increases the expression of p-PI3K, p-AKT, and p-mTOR in the myocardium (Shang et al., 2019).