YAP1 and acute kidney injury: Xu et aldetected the expression of the Hippo signaling pathway components in the kidney of a rat model of AKI and renal biopsy specimens of patients with AKI; these researchers found that YAP protein levels increase in the cytoplasm and nucleus of renal tubular epithelial cells (TECs) during the AKI repair stage, and they reported that the change of YAP expression is positively correlated with the change of TEAD expression, a YAP downstream target (Xu et al., 2016).