SH3 domain binding glutamate-rich protein-like 2 (SH3BGRL2) is critical for EMT progression and metastasis in ccRCC, and SH3BGRL2 exerts tumor inhibition through the Hippo pathway (Yin et al., 2020). The gene discussed is SH3BGRL2; the disease is nonpapillary renal cell carcinoma.