ADPKD is the most common monogene genetic system disease in humans (Bergmann et al., 2018), and it is caused by genetic mutations in PKD1 [encoding polycystin-1 (PC1)] or PKD2 [encoding polycystin-2 (PC2)] (Chapin and Caplan, 2010). Here, PKD2 is linked to autosomal dominant polycystic kidney disease.