Many studies have reported that NF2 enhances the Hippo signaling pathway through phosphorylation, isolation, degradation, and inhibition of YAP/TAZ nuclear translocation, and abnormal Hippo signaling pathway and YAP activation occurs in NF2-deficient unclassified renal cell carcinoma (uRCC) cases (Chen et al., 2016b). The gene discussed is NF2; the disease is hereditary clear cell renal cell carcinoma.