And it inhibited the activation of HSCs by regulating TGFβ1/NDRG2/MAPK signaling axis in CCl4-induced liver fibrosis (Huang et al., 2020) Our study newly found that NLPC0393 inhibited the differentiation of WB-F344 cells into cholangiocytes in a Gli1-dependent manner. The gene discussed is GLI1; the disease is Hepatic fibrosis.