INS and Hyperinsulinemia: Prolonged mitogenic signalling, such as chronic insulin exposure (hyperinsulinemia), has recently been shown to induce cell cycle re-entry in postmitotic cells, including hepatocytes (Celton-Morizur et al., 2009; Wang et al., 2017), beta cells (Aguayo-Mazzucato et al., 2019), neurons (Frade and Ovejero-Benito, 2015) and adipocytes (Li et al., 2021), with cell cycle re-entry in post-mitotic cells associated with cellular growth (Tamori and Deng, 2013; Edgar et al., 2014).