ADRB2 and obesity due to melanocortin 4 receptor deficiency: Individuals with obesity exhibit an almost 70% reduction in ADRB2 sensitivity (Reynisdottir et al., 1994; Schiffelers et al., 2001) and a 50% reduction in the number of ADRB2 positive adipocytes in obesity and hyperinsulinemia (Hagberg et al., 2018).