P2RY12 and diabetes mellitus: Since the evidence regarding the PD effectiveness of clopidogrel compared to ticagrelor in DM patients with a chronic coronary syndrome (CCS) is relatively scarce (11, 12), we designed the Comparison of Ticagrelor and clopidogrel in patients with Coronary artery disease and type 2 Diabetes Mellitus (TICS-DM) study, with the aim of assessing the platelet inhibitory effects of these two P2Y12 inhibitors in a Mediterranean population with a comprehensive panel of platelet function assays.