In-activation of tumor suppressors PTEN, TSC1, and TSC2 in TNBC is common and is associated with hyperactivation of PI3K/Akt/mTOR/4EBP1/p70S6K signaling pathway; phosphorylation of p70S6K/ 4EBP1 by mTOR has been shown to increase cancer cell survival and chemotherapy resistance in TNBC 30. The gene discussed is TSC2; the disease is cancer.